Q. When someone places a piece of paper or a tissue into a Siddur as a bookmark to save the place and keeps it there for a while, can that be thrown away? How long would that be to make a difference?
A. It would depend on the intention and the nature of the material used for the bookmark. If it is only temporary and it will be discarded promptly as usually a tissue is, it likely will not become an object of Mitzva. Not so if it is a more permanent and dedicated cardboard piece.
However, one should not use a Sefer or Siddur as a place to store tissues which are going to be used mainly for one’s body cleaning, (or were used already).
Horav Shlomo Miller’s Shlit’a opinion is similar.
Rabbi A. Bartfeld as revised By Horav Dovid Pam Shlit’a,Horav Aharon Miller Shlit’a and Horav Chanoch Ehrentreu Shlit'a